PON2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86365

Novus Biologicals, part of Bio-Techne
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NBP1-86365
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (91%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PON2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: ENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLE

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (89%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PON2 Antibody

Western Blot: PON2 Antibody [NBP1-86365]

Western Blot: PON2 Antibody [NBP1-86365]

Western Blot: PON2 Antibody [NBP1-86365] - Analysis in control (vector only transfected HEK293T lysate) and PON2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).
Immunohistochemistry-Paraffin: PON2 Antibody [NBP1-86365]

Immunohistochemistry-Paraffin: PON2 Antibody [NBP1-86365]

Immunohistochemistry-Paraffin: PON2 Antibody [NBP1-86365] - Staining in human cerebral cortex and pancreas tissues using anti-PON2 antibody. Corresponding PON2 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: PON2 Antibody [NBP1-86365]

Immunohistochemistry-Paraffin: PON2 Antibody [NBP1-86365]

Immunohistochemistry-Paraffin: PON2 Antibody [NBP1-86365] - Staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
View 2 more images

Applications for PON2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PON2

PON2 encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Long Name

Paraoxonase 2

Alternate Names

A-esterase 2, Serum Aryldialkylphosphatase 2

Gene Symbol

PON2

Additional PON2 Products

Product Documents for PON2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PON2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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