Porimin Antibody (CL14381)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26852

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (94%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # CL14381

Concentration

1 mg/ml

View all Porimin Antibodies »

Product Summary for Porimin Antibody (CL14381)

Immunogen

This antibody was developed against a Synthetic Peptide of Q8N131. Actual immunogen sequence is proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Porimin Antibody (CL14381)

Porimin Antibody (CL14381)

Immunohistochemistry-Paraffin: Porimin Antibody (CL14381) [NBP3-26852]

Staining of human testis shows moderate to strong cytoplasmic positivity in cells in seminiferous ducts.
Porimin Antibody (CL14381)

Immunohistochemistry-Paraffin: Porimin Antibody (CL14381) [NBP3-26852]

Staining of human skeletal muscle shows no positivity in myocytes as expected.
Porimin Antibody (CL14381)

Immunohistochemistry-Paraffin: Porimin Antibody (CL14381) [NBP3-26852]

Analysis in human tonsil and skeletal muscle tissues. Corresponding RNA-seq data are presented for the same tissues.
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Applications for Porimin Antibody (CL14381)

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Porimin

Porimin was identified by a monoclonal antibody developed by immunizing mice with apoptotic cells. One of these antibodies, designated anti-Porimin (for pro-oncosis receptor inducing membrane injury), was found to directly induce a unique type of cell death in Jurkat cells by binding to a 110-kDa cell surface receptor on Jurkat cells. Anti-Porimin-mediated cell death was preceded by cell aggregation, formation of plasma membrane pores, and the appearance of membrane blebs. More important, these cells show neither DNA fragmentation nor apoptotic bodies, but display lethal damage of the cell membrane.

Long Name

Pro-Oncosis Receptor Inducing Membrane Injury

Alternate Names

KCT3, TMEM123

Gene Symbol

TMEM123

Additional Porimin Products

Product Documents for Porimin Antibody (CL14381)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Porimin Antibody (CL14381)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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