Porimin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56371

Novus Biologicals, part of Bio-Techne
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NB100-56371
NB100-56371SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Bovine

Cited:

Human, Mouse

Predicted:

Chicken (93%), Rat (93%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Flow Cytometry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Porimin Antibodies »

Product Specifications

Immunogen

This antibody was generated by immunizing rabbits with a synthetic peptide corresponding to amino acids 173-188 SRRGIRYRTIDEHDAI of human Porimin; GenBank no. AAG2164.1.

Reactivity Notes

Human, Mouse reactivity reported in scientific literature (PMID: 16814713).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Porimin Antibody

Western Blot: Porimin Antibody [NB100-56371]

Western Blot: Porimin Antibody [NB100-56371]

Western Blot: Porimin Antibody [NB100-56371] - Analysis of Porimin using NB100-56371 at 2 ug/ml dilution against 20 ug/lane of HL60 cell lysate.

Applications for Porimin Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:10-1:500. Use reported in scientific literature (PMID 16814713)

Western Blot

1-3 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Porimin

Porimin was identified by a monoclonal antibody developed by immunizing mice with apoptotic cells. One of these antibodies, designated anti-Porimin (for pro-oncosis receptor inducing membrane injury), was found to directly induce a unique type of cell death in Jurkat cells by binding to a 110-kDa cell surface receptor on Jurkat cells. Anti-Porimin-mediated cell death was preceded by cell aggregation, formation of plasma membrane pores, and the appearance of membrane blebs. More important, these cells show neither DNA fragmentation nor apoptotic bodies, but display lethal damage of the cell membrane.

Long Name

Pro-Oncosis Receptor Inducing Membrane Injury

Alternate Names

KCT3, TMEM123

Entrez Gene IDs

114908 (Human); 71929 (Mouse); 363013 (Rat)

Gene Symbol

TMEM123

UniProt

Q8N131 (Human)

Additional Porimin Products

Product Documents for Porimin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Porimin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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