POT1 Antibody (S06-9I1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15080

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15080-100ul
NBP3-15080-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S06-9I1

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all POT1 Antibodies »

Product Summary for POT1 Antibody (S06-9I1)

Immunogen

A synthetic peptide of human POT1 (Uniprot#: Q9NUX5)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

71 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for POT1 Antibody (S06-9I1)

Western Blot: POT1 Antibody (S06-9I1) [NBP3-15080]

Western Blot: POT1 Antibody (S06-9I1) [NBP3-15080]

Western Blot: POT1 Antibody (S06-9I1) [NBP3-15080] - Western blot detection of POT1 in K562, C6, 3T3 cell lysates using POT1 Rabbit mAb (1:1000 diluted). Predicted band size: 71kDa. Observed band size: 71kDa.

Applications for POT1 Antibody (S06-9I1)

Application
Recommended Usage

Western Blot

1/1000-1/5000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: POT1

POT1 (protection of telomeres 1), a telomere regulator, is a single-stranded telomeric DNA-binding protein that controls telomerase-mediated telomere elongation. Telomere maintenance is required for protection against changes in telomere length, which has been implicated in ageing and certain cancers. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Excessive transcriptional expression of POT1 has been associated with stomach cancers.

Long Name

Protection of Telomeres Protein 1

Alternate Names

DKFZp586D211, HPOT1, POT1 protection of telomeres 1 homolog, POT1-like telomere end-binding protein, protection of telomeres 1 homolog (S. pombe), protection of telomeres protein 1

Gene Symbol

POT1

Additional POT1 Products

Product Documents for POT1 Antibody (S06-9I1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for POT1 Antibody (S06-9I1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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