Potassium Channel Kv3.1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-30395

Novus Biologicals, part of Bio-Techne
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NBP2-30395
NBP2-30395-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Potassium Channel Kv3.1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: EEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Potassium Channel Kv3.1 Antibody

Immunocytochemistry/ Immunofluorescence: Potassium Channel Kv3.1 Antibody [NBP2-30395]

Immunocytochemistry/ Immunofluorescence: Potassium Channel Kv3.1 Antibody [NBP2-30395]

Immunocytochemistry/Immunofluorescence: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human cell line U-2 OS shows localization to nucleus, nuclear membrane and cytosol. Antibody staining shown in green.
Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395]

Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395]

Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human kidney shows no positivity in cells in tubules as expected.
Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395]

Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395]

Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Analysis in human cerebral cortex and kidney tissues. Corresponding KCNC1 RNA-seq data are presented for the same tissues.
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Applications for Potassium Channel Kv3.1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Potassium Channel Kv3.1

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

Alternate Names

KCNC1

Gene Symbol

KCNC1

UniProt

P48547 (Human)

Additional Potassium Channel Kv3.1 Products

Product Documents for Potassium Channel Kv3.1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Potassium Channel Kv3.1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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