PP1 Inhibitor-2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-56881

Novus Biologicals, part of Bio-Techne
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NBP2-56881
NBP2-56881-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PP1 Inhibitor-2 Antibodies »

Product Summary for PP1 Inhibitor-2 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: EPSTPYHSMMGDDEDACSDTEATEAMAPDILARKLAAAEGLEPKYRIQEQESSGEEDSDLSPEEREKKRQFEMKRKLHYNEGLNIK

Reactivity Notes

Mouse 84%, Rat 81%

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PP1 Inhibitor-2 Antibody

Immunocytochemistry/ Immunofluorescence: PP1 Inhibitor-2 Antibody [NBP2-56881]

Immunocytochemistry/ Immunofluorescence: PP1 Inhibitor-2 Antibody [NBP2-56881]

Immunocytochemistry/Immunofluorescence: PP1 Inhibitor-2 Antibody [NBP2-56881] - Staining of human cell line A-431 shows localization to nucleoplasm.

Applications for PP1 Inhibitor-2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PP1 Inhibitor-2

Two inhibitors of protein phosphatase 1 (PP1) include the phosphatase inhibitor 1 (IPP-1) and phosphatase inhibitor 2 (IPP-2). IPP-2, also known as I-2, interacts with the catalytic subunit of PP1 to form the heterodimer PP1I. The PP1I complex is present in the cytosol of cells in a broad range of vertebrate and invertebrate species. Although the heterodimer itself is inactive, a reversible phosphorylation of IPP-2 at Thr 72 by glycogen-synthase-kinase (GSK3) initiates activation of the heterodimer complex in vitro. Phosphorylation of IPP-2 by casein kinase-II at Ser 86, Ser 120, and Ser 121 enhances the rate of phosphorylation by GSK3 at Thr 72 and effectively activates the heterodimer complex. Besides moderating PP1 activity, IPP-2 may play a role as a chaperone for the correct folding of PP1. The gene for human IPP-2 maps to chromosome 6 in the major histocompatiblity complex region.

Long Name

Protein Phosphatase 1 Inhibitor 2

Alternate Names

IPP2, PP1 Inhibitor2, PPP1R2

Gene Symbol

PPP1R2

Additional PP1 Inhibitor-2 Products

Product Documents for PP1 Inhibitor-2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PP1 Inhibitor-2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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