Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all PPAPDC1B/DPPL1 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human PPAPDC1B. The immunogen is located within amino acids 30 - 80 of PPAPDC1B. Amino Acid Squence: LYRNPYVEAEYFPT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PPAPDC1B/DPPL1 Antibody - BSA Free

Western Blot: PPAPDC1B/DPPL1 AntibodyBSA Free [NBP1-76244]

Western Blot: PPAPDC1B/DPPL1 AntibodyBSA Free [NBP1-76244]

Western Blot: PPAPDC1B/DPPL1 Antibody [NBP1-76244] - EL4 cell lysate with PPAPDC1B/DPPL1 antibody at (A) 1 and (B) 2 ug/mL.

Applications for PPAPDC1B/DPPL1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PPAPDC1B/DPPL1

Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide (NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. Knockdown experiments indicated that this protein is involved with multiple cell signaling pathways, including the JAK-Stat3, MAP kinase, and PKC pathways. PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22.

Alternate Names

diacylglycerol pyrophosphate like 1, DPPL1, EC 3.1.3.4, HTPAPphosphatidate phosphatase PPAPDC1B, phosphatidic acid phosphatase type 2 domain containing 1B, Phosphatidic acid phosphatase type 2 domain-containing protein 1B

Gene Symbol

PLPP5

UniProt

NP_001096029 (Human)

Additional PPAPDC1B/DPPL1 Products

Product Documents for PPAPDC1B/DPPL1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PPAPDC1B/DPPL1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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