PRMT7 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56400

Novus Biologicals, part of Bio-Techne
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NB100-56400
NB100-56400SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all PRMT7 Antibodies »

Product Summary for PRMT7 Antibody

Immunogen

Amino acids 346-360 of human PRMT7 were used as the immunogen.

Specificity

The amino acid sequence used as immunogen can be found in five different human PRMT7 isoforms: CRA_a (692 amino acids), CRA_b (613 amino acids), CRA_c (465 amino acids), CRA_d (655 amino acids) and CRA_e (567 amino acids).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PRMT7 Antibody

Western Blot: PRMT7 Antibody [NB100-56400]

Western Blot: PRMT7 Antibody [NB100-56400]

Western Blot: PRMT7 Antibody [NB100-56400] - Analysis of PRMT7 in A) HeLa and B) NIH 3T3 cell lysate using this antibody at 2 ug/ml.

Applications for PRMT7 Antibody

Application
Recommended Usage

Western Blot

1-3 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PRMT7

Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. The PRMT proteins are recruited by C-terminal activation domain-2 of the SRC (steroid receptor coactivator) GRIP-1, whereas p300 interacts with activation domain-1 in the C terminus. have identified a mammalian arginine N-methyltransferase, PRMT7, that can catalyze the formation of omega-NG-monomethyl arginine in peptides. In contrast to the other members of the PRMT family, PRMT7 was not able to methylate GST-fibrillarin or myelin basic protein or histone H2A, in vitro. It is also structurally different from other PRMTS in containing two putative AdoMet-binding motifs. Both of these domains are required for enzymatic activity.

Long Name

Protein arginine N-methyltransferase 7

Alternate Names

EC 2.1.1.321, KIAA1933

Entrez Gene IDs

54496 (Human); 214572 (Mouse)

Gene Symbol

PRMT7

UniProt

Q9NVM4 (Human)

Additional PRMT7 Products

Product Documents for PRMT7 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PRMT7 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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