Progesterone R/NR3C3 Antibody (OTI11E8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-46388

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI11E8

Concentration

1 mg/ml

View all Progesterone R/NR3C3 Antibodies »

Product Summary for Progesterone R/NR3C3 Antibody (OTI11E8)

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-298 of human PGR (NP_000917) produced in E.coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

98.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Progesterone R/NR3C3 Antibody (OTI11E8)

Western Blot: Progesterone R/NR3C3 Antibody (OTI11E8) [NBP2-46388]

Western Blot: Progesterone R/NR3C3 Antibody (OTI11E8) [NBP2-46388]

Western Blot: Progesterone R/NR3C3 Antibody (11E8) [NBP2-46388] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Progesterone R.
Immunocytochemistry/ Immunofluorescence: Progesterone R/NR3C3 Antibody (OTI11E8) [NBP2-46388]

Immunocytochemistry/ Immunofluorescence: Progesterone R/NR3C3 Antibody (OTI11E8) [NBP2-46388]

Immunocytochemistry/Immunofluorescence: Progesterone R/NR3C3 Antibody (OTI11E8) [NBP2-46388] - Staining of T47D cells using anti-PGR mouse monoclonal antibody , green, upper left; merged, upper right) or Isotype control ( merged, lower right). Cell nuclei were stained with DAPI (blue, lower left) (1:100).
Immunohistochemistry: Progesterone R/NR3C3 Antibody (OTI11E8) [NBP2-46388]

Immunohistochemistry: Progesterone R/NR3C3 Antibody (OTI11E8) [NBP2-46388]

Immunohistochemistry: Progesterone R/NR3C3 Antibody (11E8) [NBP2-46388] - Analysis of Human tonsil tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
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Applications for Progesterone R/NR3C3 Antibody (OTI11E8)

Application
Recommended Usage

Flow Cytometry

1:100

Immunohistochemistry

1:150

Immunohistochemistry-Paraffin

1:150

Western Blot

1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Progesterone R/NR3C3

The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription.

Long Name

Progesterone Receptor

Alternate Names

NR3C3, PGR, ProgesteroneR

Gene Symbol

PGR

Additional Progesterone R/NR3C3 Products

Product Documents for Progesterone R/NR3C3 Antibody (OTI11E8)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Progesterone R/NR3C3 Antibody (OTI11E8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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