Prokineticin 2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-46142

Novus Biologicals, part of Bio-Techne
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NBP1-46142
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Prokineticin 2 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-HPLTRKNNFGNGRQE corresponding to internal region according to NP_001119600.1.

Epitope

internal region

Specificity

This antibody is expected to recognize isoform a (NP_001119600.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Prokineticin 2 Antibody

Immunohistochemistry-Paraffin: Prokineticin 2 Antibody [NBP1-46142]

Immunohistochemistry-Paraffin: Prokineticin 2 Antibody [NBP1-46142]

Immunohistochemistry-Paraffin: Prokineticin 2 Antibody [NBP1-46142] - 3.75ug/ml staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for Prokineticin 2 Antibody

Application
Recommended Usage

Immunohistochemistry

1 ug/ml

Peptide ELISA

Detection limit 1:32000

Western Blot

detection limit 1:32000
Application Notes
Western blot: Preliminary experiments in Human Ileum lysates gave no specific signal but low background
IHC: Paraffin embedded Human Testis.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Prokineticin 2

Prokineticin 2 is known to regulate many different biological functions, including neurogenesis, smooth muscle contractility, angiogenesis and circadian rhythm. In serving the latter role, prokineticin 2 functions as an output molecule from the suprachiasmatic nucleus (SCN) of the hypothalamus, that transmits behavioral rhythms, but may also function locally within the SCN to synchronize output. Prokineticin 2 expression is induced by CLOCK and BMAL1 heterodimers and light, and is inhibited by period genes (PER1, PER2 and PER3) and cryptochrome genes (CRY1 and CRY2). Expression is reported in the SCN and among a few other discrete brain areas, including the islands of Calleja, media l preoptic area of the hypothalamus and the shell of the nucleus accumbens as well as in the testis, prostate and, at lower levels, in the small intestine.

Long Name

Prokineticin-2

Alternate Names

BV8, PROK2, Protein Bv8 homolog

Entrez Gene IDs

60675 (Human)

Gene Symbol

PROK2

UniProt

NP_001119600.1 (Human)

Additional Prokineticin 2 Products

Product Documents for Prokineticin 2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Prokineticin 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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