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Proprotein Convertase 9/PCSK9 Antibody (alirocumab)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28572

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # alirocumab

Concentration

LYOPH mg/ml

Product Specifications

Immunogen

PCSK9

Reactivity Notes

Predicted species reactivity: Mouse, Cynomolgus

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Also known as 'alirocumab'.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for Proprotein Convertase 9/PCSK9 Antibody (alirocumab)

Proprotein Convertase 9/PCSK9 Antibody (alirocumab)

ELISA: Proprotein Convertase 9/PCSK9 Antibody (alirocumab)[NBP3-28572] -

Immobilized human PCSK9 chis at 2 ug/mL can bind Proprotein Convertase 9/PCSK9 Antibody (alirocumab), EC50=0.04823 ug/mL.

Applications for Proprotein Convertase 9/PCSK9 Antibody (alirocumab)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Proprotein Convertase 9/PCSK9

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Alternate Names

FH3, FHCL3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, PCSK9

Gene Symbol

PCSK9

UniProt

Additional Proprotein Convertase 9/PCSK9 Products

Product Documents for Proprotein Convertase 9/PCSK9 Antibody (alirocumab)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Proprotein Convertase 9/PCSK9 Antibody (alirocumab)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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