Proteasome 19S 10B Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-19950

Novus Biologicals, part of Bio-Techne
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NBP2-19950
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Proteasome 19S 10B Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human Proteasome 19S 10B. The exact sequence is proprietary.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

100 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Proteasome 19S 10B Antibody

Western Blot: Proteasome 19S 10B Antibody [NBP2-19950]

Western Blot: Proteasome 19S 10B Antibody [NBP2-19950]

Western Blot: Proteasome 19S 10B Antibody [NBP2-19950] - Sample (30 ug of whole cell lysate) A: JC B: BCL-1 7. 5% SDS PAGE gel, diluted at 1:1000.
Immunocytochemistry/ Immunofluorescence: Proteasome 19S 10B Antibody [NBP2-19950]

Immunocytochemistry/ Immunofluorescence: Proteasome 19S 10B Antibody [NBP2-19950]

Immunocytochemistry/Immunofluorescence: Proteasome 19S 10B Antibody [NBP2-19950] - Immunofluorescence analysis of methanol-fixed A431, using antibody at 1:500 dilution.
Western Blot: Proteasome 19S 10B Antibody [NBP2-19950]

Western Blot: Proteasome 19S 10B Antibody [NBP2-19950]

Western Blot: Proteasome 19S 10B Antibody [NBP2-19950] - Sample (30 ug of whole cell lysate) A: A431 5% SDS PAGE gel, diluted at 1:500.

Applications for Proteasome 19S 10B Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 20% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Proteasome 19S 10B

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. [provided by RefSeq]

Alternate Names

26S proteasome regulatory subunit RPN1, 26S proteasome regulatory subunit S2, MGC14274,55.11 protein, P97, proteasome (prosome, macropain) 26S subunit, non-ATPase, 2, Protein 55.11, Rpn1, S226S proteasome non-ATPase regulatory subunit 2, TNFR-associated protein 2, TRAP226S proteasome subunit p97, tumor necrosis factor receptor-associated protein 2, Tumor necrosis factor type 1 receptor-associated protein 2

Gene Symbol

PSMD2

UniProt

Q13200 (Human)

Additional Proteasome 19S 10B Products

Product Documents for Proteasome 19S 10B Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Proteasome 19S 10B Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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