Proteasome 19S S7 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-3322

Novus Biologicals, part of Bio-Techne
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NB120-3322
NB120-3322-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Proteasome 19S S7 Antibodies »

Product Summary for Proteasome 19S S7 Antibody

Immunogen

Human recombinant proteasome 19S subunit S7.

Specificity

Detects proteasome 19S subunit S7.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

48 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Proteasome 19S S7 Antibody

Western Blot: Proteasome 19S S7 Antibody [NB120-3322]

Western Blot: Proteasome 19S S7 Antibody [NB120-3322]

Western Blot: Proteasome 19S S7 Antibody [NB120-3322] - Analysis of proteasome 19S subunit S7 on HeLa cell lysate.

Applications for Proteasome 19S S7 Antibody

Application
Recommended Usage

Immunoprecipitation

1:10 - 1:500

Western Blot

1:1000
Application Notes
WB: Detects an approx. 47 kDa protein representing proteasome 19S subunit S7 from HeLa cell lysate.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Ammonium sulfate precipitation

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Proteasome 19S S7

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

Alternate Names

26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, MGC3004, MSS1ATPase, 2, proteasome (prosome, macropain) 26S subunit, ATPase, 2, Protein MSS1, putative protein product of Nbla10058

Entrez Gene IDs

5701 (Human)

Gene Symbol

PSMC2

UniProt

P35998 (Human)

Additional Proteasome 19S S7 Products

Product Documents for Proteasome 19S S7 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Proteasome 19S S7 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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