Protein Phosphatase inhibitor 1 Antibody (SR3103)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27703

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-27703-100ul
NBP3-27703-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR3103

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Protein Phosphatase inhibitor 1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Protein Phosphatase inhibitor 1 (Uniprot #: Q13522)

Specificity

Detects endogenous levels of Protein Phosphatase inhibitor 1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

27 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Protein Phosphatase inhibitor 1 Antibody (SR3103)

Western Blot: Protein Phosphatase inhibitor 1 Antibody (SR3103) [NBP3-27703] -

Western Blot: Protein Phosphatase inhibitor 1 Antibody (SR3103) [NBP3-27703] - Western blot analysis of Rat brain lysate.

Applications for Protein Phosphatase inhibitor 1 Antibody (SR3103)

Application
Recommended Usage

Flow Cytometry

1:20

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Immunoprecipitation

1:50

Western Blot

1:5000-1:20000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 150mM NaCl, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Protein Phosphatase inhibitor 1

The inhibitor of protein phosphatase 1 (IPP-1, I-1) is an endogenous inhibitor of protein phophastase 1 (PP-1), a signal transducer in many cellular pathways. IPP-1 is a member of heat-stable PP1 inhibitory subunits, which includes DARPP-32, (a homologue of IPP-1) and IPP-2. First discovered in rabbit skeletal muscle, IPP-1 is expressed in various mammalian tissues. IPP-1 inhibition of PP-1 is controlled through phosphorylation at Thr35 by cAMP-dependent protein kinase and a tetra-peptide consensus motif in various PP-1 binding proteins (1). IPP-1 is a hormonal control in muscle contraction, pituitary cell growth, synaptic plasticity by neurotransmitters, and glycogen metabolism (2). In vivo, IPP-1 is phosphorylated at Ser-67 by NCLK, which also initiates inhibition of PP-1 by IPP-1 (3). Triggered by increase in calcium level, IPP-1 is inactivated by PP2B through de-phosphorylation (4).

Alternate Names

I1, I-1, IPP-1, IPP1inhibitor-1, protein phosphatase 1 regulatory subunit 1A, protein phosphatase 1, regulatory (inhibitor) subunit 1A, Protein phosphatase inhibitor 1, protein phosphatase inhibitor-1

Gene Symbol

PPP1R1A

Additional Protein Phosphatase inhibitor 1 Products

Product Documents for Protein Phosphatase inhibitor 1 Antibody (SR3103)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Protein Phosphatase inhibitor 1 Antibody (SR3103)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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