PSMC3 Antibody (OTI9F3)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-02316

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Canine

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI9F3

Concentration

0.58 mg/ml

View all PSMC3 Antibodies »

Product Specifications

Immunogen

Full length human recombinant protein of human PSMC3(NP_002795) produced in HEK293T cell.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

49.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PSMC3 Antibody (OTI9F3)

Western Blot: PSMC3 Antibody (OTI9F3) [NBP2-02316]

Western Blot: PSMC3 Antibody (OTI9F3) [NBP2-02316]

Western Blot: PSMC3 Antibody (OTI9F3) [NBP2-02316] - Analysis of extracts (35ug) from 9 different cell lines by using anti-PSMC3 monoclonal antibody.
Immunocytochemistry/ Immunofluorescence: PSMC3 Antibody (OTI9F3) [NBP2-02316]

Immunocytochemistry/ Immunofluorescence: PSMC3 Antibody (OTI9F3) [NBP2-02316]

Immunocytochemistry/Immunofluorescence: PSMC3 Antibody (OTI9F3) [NBP2-02316] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY PSMC3.
Immunohistochemistry-Paraffin: PSMC3 Antibody (OTI9F3) [NBP2-02316]

Immunohistochemistry-Paraffin: PSMC3 Antibody (OTI9F3) [NBP2-02316]

Immunohistochemistry-Paraffin: PSMC3 Antibody (OTI9F3) [NBP2-02316] - Staining of paraffin-embedded prostate tissue using anti-PSMC3 mouse monoclonal antibody.
View 7 more images

Applications for PSMC3 Antibody (OTI9F3)

Application
Recommended Usage

Flow Cytometry

1:100

Immunocytochemistry/ Immunofluorescence

1:100

Immunohistochemistry

1:50

Immunohistochemistry-Paraffin

1:50

Western Blot

1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

0.58 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PSMC3

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits.Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Alternate Names

human immunodeficiency virus tat transactivator binding protein-1, MGC8487, proteasome (prosome, macropain) 26S subunit, ATPase, 3,26S proteasome AAA-ATPase subunit RPT5, Proteasome 26S subunit ATPase 3, Proteasome subunit P50, TBP-126S protease regulatory subunit 6A, TBP1Tat-binding protein 1

Entrez Gene IDs

868 (Human)

Gene Symbol

CBLB

Additional PSMC3 Products

Product Documents for PSMC3 Antibody (OTI9F3)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PSMC3 Antibody (OTI9F3)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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