PTBP1 Antibody (S01-1G2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19910

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19910-100ul
NBP3-19910-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S01-1G2

Concentration

0.3 mg/ml

View all PTBP1 Antibodies »

Product Summary for PTBP1 Antibody (S01-1G2)

Immunogen

A synthetic peptide of human PTBP1 (Uniprot # P26599)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PTBP1 Antibody (S01-1G2)

Western Blot: PTBP1 Antibody (S01-1G2) [NBP3-19910]

Western Blot: PTBP1 Antibody (S01-1G2) [NBP3-19910]

Western Blot: PTBP1 Antibody (S01-1G2) [NBP3-19910] - Western blot detection of PTBP1 in Hela, CHO-K1, Ramos using NBP3-19910 (1:1000 diluted)
Immunohistochemistry-Paraffin: PTBP1 Antibody (S01-1G2) [NBP3-19910]

Immunohistochemistry-Paraffin: PTBP1 Antibody (S01-1G2) [NBP3-19910]

Immunohistochemistry-Paraffin: PTBP1 Antibody (S01-1G2) [NBP3-19910] - Immunohistochemistry of PTBP1 in paraffin-embedded Human tonsil using NBP3-19910 at dilution 1/50

Applications for PTBP1 Antibody (S01-1G2)

Application
Recommended Usage

Immunohistochemistry

1/50

Western Blot

1/2000-1/10000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PTBP1

PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternate Names

Heterogeneous nuclear ribonucleoprotein I, heterogeneous nuclear ribonucleoprotein polypeptide I, hnRNP I, HNRNPI, HNRNP-I, HNRPI, MGC10830, MGC8461, polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoproteinI), polypyrimidine tract binding protein 1, polypyrimidine tract-binding protein 1, pPTB, PTB-1, PTB2, PTB3, PTB4, PTB57 kDa RNA-binding protein PPTB-1, PTB-T, RNA-binding protein

Gene Symbol

PTBP1

Additional PTBP1 Products

Product Documents for PTBP1 Antibody (S01-1G2)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PTBP1 Antibody (S01-1G2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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