PXR/NR1I2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-58514

Novus Biologicals, part of Bio-Techne
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NBP2-58514
NBP2-58514-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PXR/NR1I2 Antibodies »

Product Summary for PXR/NR1I2 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: VQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PXR/NR1I2 Antibody

Immunocytochemistry/ Immunofluorescence: PXR/NR1I2 Antibody [NBP2-58514]

Immunocytochemistry/ Immunofluorescence: PXR/NR1I2 Antibody [NBP2-58514]

Immunocytochemistry/Immunofluorescence: PXR/NR1I2 Antibody [NBP2-58514] - Staining of human cell line U-251 MG shows localization to nucleoplasm.

Applications for PXR/NR1I2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PXR/NR1I2

NR1I2 product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Long Name

Pregnane X Receptor

Alternate Names

BXR, NR1I2, ONR1, PAR1, PAR2, SXR

Gene Symbol

NR1I2

Additional PXR/NR1I2 Products

Product Documents for PXR/NR1I2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for PXR/NR1I2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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