Rab5b Antibody - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-94902

Novus Biologicals, part of Bio-Techne
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NBP2-94902-0.02ml
NBP2-94902-0.1ml
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

Azide and BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Rab5b Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RAB5B (NP_002859.1). YDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSRGVD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Rab5b Antibody - Azide and BSA Free

Western Blot: Rab5b AntibodyAzide and BSA Free [NBP2-94902]

Western Blot: Rab5b AntibodyAzide and BSA Free [NBP2-94902]

Western Blot: Rab5b Antibody [NBP2-94902] - Analysis of extracts of various cell lines, using Rab5b . Exposure time: 90s.
Immunocytochemistry/ Immunofluorescence: Rab5b Antibody - Azide and BSA Free [NBP2-94902]

Immunocytochemistry/ Immunofluorescence: Rab5b Antibody - Azide and BSA Free [NBP2-94902]

Immunocytochemistry/Immunofluorescence: Rab5b Antibody [NBP2-94902] - Analysis of L929 cells using Rab5b at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry: Rab5b Antibody - Azide and BSA Free [NBP2-94902]

Immunohistochemistry: Rab5b Antibody - Azide and BSA Free [NBP2-94902]

Immunohistochemistry: Rab5b Antibody [NBP2-94902] - Analysis of human colon carcinoma using Rab5b at dilution of 1:100. Blue: DAPI for nuclear staining.

Applications for Rab5b Antibody - Azide and BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.3), 50% glycerol

Format

Azide and BSA Free

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Rab5b

Rab5b is a member of the Rab family of small (monomeric) G proteins. Like other small G proteins, Rab5b switches between an inactive, GDP-form and an active, GTP-bound form. GDP/GTP exchange factors (GEFs) catalyse the conversion from the GDP-bound form to the GTP-bound form, while GTPase-activating proteins (GAPs) catalyse GTP hydrolysis to GDP. Rab5b is involved in endocytosis and recycling of cell surface molecules. It interacts with RIN2 and RIN3, which regulate its function, possibly by acting as GEFs. Knockdown of Rab5b abolished group I metabotropic glutamate receptor (mGluR)-mediated neuroprotection. Furthermore, Rab5b interacts with LRRK2, the defective gene at the PARK8 locus that results in Parkinson's disease. Roles for Rab5b in neurodegenerative disease, neuroprotection, and synaptic plasticity have been suggested.

Alternate Names

RAB5B, member RAS oncogene family, ras-related protein Rab-5B

Gene Symbol

RAB5B

Additional Rab5b Products

Product Documents for Rab5b Antibody - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Rab5b Antibody - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including Methotrexate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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