RAB8A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-93433

Novus Biologicals, part of Bio-Techne
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NB100-93433
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all RAB8A Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-NQGVKITPDQQKR corresponding to C-Terminus according to NP_005361.2.

Epitope

C-NQGVKITPDQQKR

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for RAB8A Antibody

Western Blot: RAB8A Antibody [NB100-93433]

Western Blot: RAB8A Antibody [NB100-93433]

Western Blot: RAB8A Antibody [NB100-93433] - (0.1ug/ml) staining of Human Brain (Cerebellum) 35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for RAB8A Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.1 - 0.3 ug/ml
Application Notes
WB: Approx. 25 kDa band observed in human brain (cerebellum), kidney and heart lysates (calculated MW of 23.7 kDa band according to NP_005361.2).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RAB8A

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq]

Long Name

Ras-related protein Rab-8A

Alternate Names

MEL, Oncogene c-mel, RAB8

Entrez Gene IDs

4218 (Human)

Gene Symbol

RAB8A

UniProt

NP_005361.2 (Human)

Additional RAB8A Products

Product Documents for RAB8A Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for RAB8A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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