Rad17 [p Ser656] Antibody (SR2259)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21602

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21602-100ul
NBP3-21602-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2259

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Rad17 Antibodies »

Product Summary for Rad17 [p Ser656] Antibody (SR2259)

Immunogen

A synthesized peptide derived from human phospho-Rad17 [Ser656] (Uniprot #: O75943)

Modification

p Ser 656

Specificity

Detects endogenous levels of total phospho-Rad17 [Ser656]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

85 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Rad17 [p Ser656] Antibody (SR2259)

Western Blot: Rad17 [p Ser 656] Antibody (SR2259) [NBP3-21602] -

Western Blot: Rad17 [p Ser 656] Antibody (SR2259) [NBP3-21602] - Western blot analysis using NBP3-21602 in (1) HeLa cell treated with CA lysate; (2) HeLa cell lysate.

Applications for Rad17 [p Ser656] Antibody (SR2259)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Rad17

Signals originating from damaged DNA activate checkpoint pathways and target the mitotic apparatus via a number a distinct mechanisms. These checkpoints link damage to DNA with the components of the cell cycle through signal transduction systems. In mammals, five genes have been identified as components of DNA damage-induced checkpoint pathways: ATM, p53, p21/WAF1/CIP1, hCHK1, and 14-3-3sigma. When overexpressed in mammalian cells, hRAD17 activates p53 and causes an accumulation of G1 phase cells, suggesting an involvement of the hRAD17 gene in this checkpoint pathway.(1).

Alternate Names

CCYC, cell cycle checkpoint protein (RAD17), cell cycle checkpoint protein RAD17, FLJ41520, hRad17, R24L, RAD1 (S. pombe) homolog, RAD1 homolog, RAD17 homolog (S. pombe), Rad17-like protein, RAD17Sp, Rad24, RF-C activator 1 homolog, RF-C/activator 1 homolog

Gene Symbol

RAD17

Additional Rad17 Products

Product Documents for Rad17 [p Ser656] Antibody (SR2259)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Rad17 [p Ser656] Antibody (SR2259)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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