Rad21 Antibody (SR2172)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21658

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21658-100ul
NBP3-21658-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Flow Cytometry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2172

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Rad21 Antibodies »

Product Summary for Rad21 Antibody (SR2172)

Immunogen

A synthesized peptide derived from human Rad21 (Uniprot #: O60216)

Specificity

Detects endogenous levels of total Rad21

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Rad21 Antibody (SR2172)

Western Blot: Rad21 Antibody (SR2172) [NBP3-21658] -

Western Blot: Rad21 Antibody (SR2172) [NBP3-21658] - Western blot analysis using NBP3-21658 in HeLa cell lysate.

Applications for Rad21 Antibody (SR2172)

Application
Recommended Usage

Flow Cytometry

1:50

Western Blot

1:500-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Rad21

The cohesin complex plays an important role in tethering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys the cohesin complex by means of cleavaging its Scc1 subunit (Mcd1/Scc1/hRad21), allowing the chromatids to separate and divide with the cell. During apoptosis the C-terminal portion of hRad21 is cleaved and translocated to the cytoplasm. This cleavage and translocation may act as a nuclear signal that promotes and accelerates subsequent events of apoptosis (2).

Alternate Names

double-strand-break repair protein rad21 homolog, hHR21FLJ25655, HR21, KIAA0078RAD21 (S. pombe) homolog, MCD1, Nuclear matrix protein 1, NXP-1, NXP1HRAD21, protein involved in DNA double-strand break repair, RAD21 homolog (S. pombe), SCC1 homolog, SCC1FLJ40596

Gene Symbol

RAD21

Additional Rad21 Products

Product Documents for Rad21 Antibody (SR2172)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Rad21 Antibody (SR2172)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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