RanBP3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-2939

Novus Biologicals, part of Bio-Techne
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NB120-2939
NB120-2939-50ug
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Key Product Details

Species Reactivity

Human, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all RanBP3 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues M(1) A D L A N E E K P A L A(13) C of human RanBP3.

Specificity

Detects Ran binding protein 3 (RanBP 3) from human and rat cells.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RanBP3 Antibody

Western Blot: RanBP3 Antibody [NB120-2939]

Western Blot: RanBP3 Antibody [NB120-2939]

Western Blot: RanBP3 Antibody [NB120-2939] - Analysis of RanBP3 from HeLa cytosol.
Immunohistochemistry: RanBP3 Antibody [NB120-2939]

Immunohistochemistry: RanBP3 Antibody [NB120-2939]

Immunohistochemistry: RanBP3 Antibody [NB120-2939] - Figure 1: IHC staining of RanBP3 in NRK cells. Figure 2: WB of RanBP3 from HeLa cytosol.

Applications for RanBP3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

10 ug/ml

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Paraffin

1:10 - 1:500

Western Blot

10 ug/ml
Application Notes
WB: Detects an approx. 60 kDa protein representing RanBP 3 from HeLa cell extracts. IF: Staining of RanBP 3 in NRK cells results in diffuse nuclear staining.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RanBP3

Transport of macromolecules into and out of the nucleus occurs through nuclear pore complexes (NPC). This energy-dependent process involves nucleoporins at the NPC, associated transport proteins and GTP. The GTPase Ran is a small protein that belongs to the RAS protein superfamily and is found associated with the nuclear membrane. Ran GTPase is essential for mRNA processing, nuclear transport, cell cycle control, mitotic spindle assembly, and postmitotic nuclear re-assembly and nuclear architecture maintenance. Ran binding proteins (RanBPs) belong to a family of proteins that bind Ran GTPase and help to stimulate its GTPase activity. Members of the RanBP family show weak similarity to importin beta, a protein involved in the transport of proteins to the nuclear membrane. RanBP3 functions as a cofactor for CRM1-mediated nuclear export and stimulates export by enhancing the affinity of CRM1 for RanGTP and substrate.

Alternate Names

DKFZp586I1520, RAN binding protein 3, ran-binding protein 3, RAN-binding protein-3, RanBP3

Entrez Gene IDs

8498 (Human); 501281 (Rat)

Gene Symbol

RANBP3

Additional RanBP3 Products

Product Documents for RanBP3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for RanBP3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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