RB1CC1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-77317

Novus Biologicals, part of Bio-Techne
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NB100-77317
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all RB1CC1 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 250 and 300 human 200 kDa FAK family kinase-interacting protein (RB1-inducible coiled-coil 1) using the numbering given in entry NP_055596.2 (GeneID 9821).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RB1CC1 Antibody

Immunoprecipitation: RB1CC1 Antibody [NB100-77317]

Immunoprecipitation: RB1CC1 Antibody [NB100-77317]

Immunoprecipitation: RB1CC1 Antibody [NB100-77317] - Detection of Human FIP200/RB1CC1 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-FIP200/RB1CC1 antibody NB100-77317 used for IP at 3 mcg/mg lysate. FIP200/RB1CC1 was also immunoprecipitated by rabbit anti-FIP200/RB1CC1 antibody NB10077279, which recognizes a downstream epitope. Detection: Chemiluminescence with an exposure time of 30 seconds.

Applications for RB1CC1 Antibody

Application
Recommended Usage

Immunoprecipitation

1:10-1:500
Application Notes
This antibody is not recommended for Western Blot analysis.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: RB1CC1

FIP200 (FAK-family interacting protein of 200 kDa) appears to play several key roles related to cell growth, proliferation, development, and tumorigenesis. FIP200 was originally identified in a yeast two-hybrid screen for Pyk2 kinase interacting proteins. It was later identified as a protein that interacts with FAK (focal adhesion kinase), a signal transducing protein that mediates signals from the extracellular matrix to the cytoskeleton to influence cell motility, and cell cycle progression. FIP200 is also known as RB1CC1 (RB1-inducible coiled-coil 1) and has been found to function as a regulator of the retinoblastoma 1 (RB1) tumor suppressor. FIP200 associates with the tumor suppressor TSC1 which partners with TSC2 to antagonize the mTOR signaling pathway. FIP200 association with TSC2 promotes mTOR activity by interfering with the antagonistic effects of the TSC1-TSC2 complex.

Alternate Names

CC1, DRAGOU14, FIP200, KIAA0203200 kDa FAK family kinase-interacting protein, RB1-inducible coiled-coil 1, RB1-inducible coiled-coil protein 1, RBICC

Entrez Gene IDs

9821 (Human)

Gene Symbol

RB1CC1

UniProt

NP_055596.2 (Human)

Additional RB1CC1 Products

Product Documents for RB1CC1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for RB1CC1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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