RBX1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00009978-B01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all RBX1 Antibodies »

Product Specifications

Immunogen

RBX1 (AAH01466, 1 a.a. - 108 a.a.) full-length human protein. MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for RBX1 Antibody

Western Blot: RBX1 Antibody [H00009978-B01P]

Western Blot: RBX1 Antibody [H00009978-B01P]

Western Blot: RBX1 Antibody [H00009978-B01P] - Analysis of RBX1 expression in transfected 293T cell line by RBX1 polyclonal antibody. Lane 1: RBX1 transfected lysate(11.99 KDa). Lane 2: Non-transfected lysate.
Immunocytochemistry/ Immunofluorescence: RBX1 Antibody [H00009978-B01P]

Immunocytochemistry/ Immunofluorescence: RBX1 Antibody [H00009978-B01P]

Immunocytochemistry/Immunofluorescence: RBX1 Antibody [H00009978-B01P] - Analysis of purified antibody to RBX1 on 293 cell. (antibody concentration 1 ug/ml)
Immunocytochemistry/ Immunofluorescence: RBX1 Antibody [H00009978-B01P]

Immunocytochemistry/ Immunofluorescence: RBX1 Antibody [H00009978-B01P]

Immunocytochemistry/Immunofluorescence: RBX1 Antibody [H00009978-B01P] - Analysis of purified antibody to RBX1 on HeLa cell. (antibody concentration 10 ug/ml)

Applications for RBX1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This antibody is useful for Western Blot, Functional, Immunofluorescence
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: RBX1

ROC1 is a component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC1 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. The RING-type zinc finger domain is essential for ubiquitin ligase activity. ROC1 probably also stimulates CDC34 autoubiquitination and promotes the neddylation of CUL1 and probably CUL2. ROC1 has a cytoplasmic and nuclear localization and is widely expressed in most tissues.

Long Name

Ring-Box 1

Alternate Names

Ring Box 1, RNF75, ZYP Protein

Gene Symbol

RBX1

UniProt

AAH01466 (Human)

Additional RBX1 Products

Product Documents for RBX1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for RBX1 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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