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RNF34 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1202

Novus Biologicals, part of Bio-Techne
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NB100-1202

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

Product Specifications

Immunogen

Peptide with sequence KAGATSMWASCC corresponding to N-Terminus according to NP_079402.2.

Specificity

This antibody is expected to recognize both reported isoforms (NP_919247.1 and NP_079402.2).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for RNF34 Antibody

Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202]

Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202]

Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202] - (3.8ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202]

Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202]

Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202] - (4ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.

Applications for RNF34 Antibody

Application
Recommended Usage

Immunohistochemistry

4 - 8 ug/ml

Immunohistochemistry-Paraffin

1:10 - 1:500

Peptide ELISA

Detection limit 1:32000
Application Notes
WB: No signal obtained yet but low background observed in human testis lysate at up to 1 ug/ml. IHC-P: Human kidney shows cytoplasm staining in select DCT.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RNF34

The protein encoded by the RNF34 gene contains a RINF finger, a motif known to be involved in protein-protein andprotein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as amodulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alphainduced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have beenreported. (provided by RefSeq)

Alternate Names

CARP1, Caspase regulator CARP1, Caspases-8 and -10-associated RING finger protein 1, E3 ubiquitin-protein ligase RNF34, EC 6.3.2, EC 6.3.2.-, FLJ21786, FYVE-RING finger protein Momo, hRFI, Human RING finger homologous to inhibitor of apoptosis protein, RFI, RIF, RIFF, ring finger protein 34CARP-1, RING finger protein RIFF

Entrez Gene IDs

80196 (Human); 80751 (Mouse); 282845 (Rat)

Gene Symbol

RNF34

Additional RNF34 Products

Product Documents for RNF34 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for RNF34 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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