RNF34 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1202

Novus Biologicals, part of Bio-Techne
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NB100-1202
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all RNF34 Antibodies »

Product Specifications

Immunogen

Peptide with sequence KAGATSMWASCC corresponding to N-Terminus according to NP_079402.2.

Specificity

This antibody is expected to recognize both reported isoforms (NP_919247.1 and NP_079402.2).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for RNF34 Antibody

Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202]

Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202]

Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202] - (3.8ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202]

Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202]

Immunohistochemistry-Paraffin: RNF34 Antibody [NB100-1202] - (4ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.

Applications for RNF34 Antibody

Application
Recommended Usage

Immunohistochemistry

4 - 8 ug/ml

Immunohistochemistry-Paraffin

1:10 - 1:500

Peptide ELISA

Detection limit 1:32000
Application Notes
WB: No signal obtained yet but low background observed in human testis lysate at up to 1 ug/ml. IHC-P: Human kidney shows cytoplasm staining in select DCT.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RNF34

The protein encoded by the RNF34 gene contains a RINF finger, a motif known to be involved in protein-protein andprotein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as amodulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alphainduced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have beenreported. (provided by RefSeq)

Alternate Names

CARP1, Caspase regulator CARP1, Caspases-8 and -10-associated RING finger protein 1, E3 ubiquitin-protein ligase RNF34, EC 6.3.2, EC 6.3.2.-, FLJ21786, FYVE-RING finger protein Momo, hRFI, Human RING finger homologous to inhibitor of apoptosis protein, RFI, RIF, RIFF, ring finger protein 34CARP-1, RING finger protein RIFF

Entrez Gene IDs

80196 (Human); 80751 (Mouse); 282845 (Rat)

Gene Symbol

RNF34

UniProt

NP_079402 (Human)

Additional RNF34 Products

Product Documents for RNF34 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for RNF34 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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