ROR gamma/RORC/NR1F3 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS5188

Novus Biologicals, part of Bio-Techne
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NLS5188
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Predicted:

Canine (93%), Monkey (93%), Orangutan (93%), Primate (100%). Backed by our 100% Guarantee.

Applications

Validated:

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all ROR gamma/RORC/NR1F3 Antibodies »

Product Specifications

Immunogen

Synthetic 14 amino acid peptide from modulating domain of human ROR gamma/RORC/NR1F3.

Epitope

Modulating domain

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (86%), Mouse (86%), Rat (86%), Bat (86%), Bovine (86%).

Localization

Nuclear

Specificity

Human ROR gamma/RORC/NR1F3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for ROR gamma/RORC/NR1F3 Antibody - BSA Free

Immunohistochemistry-Paraffin: ROR gamma/RORC/NR1F3 Antibody - BSA Free [NLS5188]

Immunohistochemistry-Paraffin: ROR gamma/RORC/NR1F3 Antibody - BSA Free [NLS5188]

Immunohistochemistry-Paraffin: ROR gamma/RORC/NR1F3 Antibody [NLS5188] - Analysis of anti-ROR Gamma antibody with human thymus.

Applications for ROR gamma/RORC/NR1F3 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100 - 1:2000

Immunohistochemistry-Paraffin

10 - 15 ug/ml
Application Notes
.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: ROR gamma/RORC/NR1F3

ROR gamma, a NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L). ROR gamma is also required for the development of lymph nodes and Peyer's patches. It has been shown that ROR gamma t, a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes. ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence. ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and kidney, and in human skeletal muscle. ESTs have been isolated from human tissue libraries, including cancerous head/neck, germ cell, and prostate, and normal colon, head/neck, lung, liver/spleen, and pancreas.

Long Name

Retinoic Acid-Related Orphan Receptor gamma

Alternate Names

NR1F3, RORC, RZRG

Entrez Gene IDs

6097 (Human)

Gene Symbol

RORC

UniProt

P51449

Additional ROR gamma/RORC/NR1F3 Products

Product Documents for ROR gamma/RORC/NR1F3 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for ROR gamma/RORC/NR1F3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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