RP105/CD180 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87727

Novus Biologicals, part of Bio-Techne
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NBP1-87727
NBP1-87727-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all RP105/CD180 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: DFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTVFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGMKGLNLLKKL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RP105/CD180 Antibody

Immunohistochemistry-Paraffin: RP105/CD180 Antibody [NBP1-87727]

Immunohistochemistry-Paraffin: RP105/CD180 Antibody [NBP1-87727]

Immunohistochemistry-Paraffin: RP105/CD180 Antibody [NBP1-87727] - Staining of human tonsil shows high expression.
Immunohistochemistry-Paraffin: RP105/CD180 Antibody [NBP1-87727]

Immunohistochemistry-Paraffin: RP105/CD180 Antibody [NBP1-87727]

Immunohistochemistry-Paraffin: RP105/CD180 Antibody [NBP1-87727] - Staining of human cerebral cortex shows low expression as expected.
Immunohistochemistry-Paraffin: RP105/CD180 Antibody [NBP1-87727]

Immunohistochemistry-Paraffin: RP105/CD180 Antibody [NBP1-87727]

Immunohistochemistry-Paraffin: RP105/CD180 Antibody [NBP1-87727] - Staining in human tonsil and cerebral cortex tissues using anti-CD180 antibody. Corresponding CD180 RNA-seq data are presented for the same tissues.

Applications for RP105/CD180 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: RP105/CD180

CD180, also known as RP105, is a 105 kD member of the toll-like receptor (TLR) family and is expressed on most B cells, monocytes/macrophages and dendritic cells. The TLR family's structural characteristics are critically involved in protein-protein signaling interactions leading to the activation of the innate immune system. Additionally, MD-1, a secretory protein, associates with CD180 (RP105) at the cell surface and this complex, in conjunction with TLR4, recognizes bacterial LPS. The human CD180 (RP105) gene maps to 5q12. The MHR73-11 antibody is able to activate B cells and to protect against irradiation- or dexamethasone-induced apoptosis.

Alternate Names

CD180, Ly64

Gene Symbol

CD180

Additional RP105/CD180 Products

Product Documents for RP105/CD180 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for RP105/CD180 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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