RSK1 [p Thr359, p Ser363] Antibody (RM233)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61584

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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NBP2-61584
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM233

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all RSK1 Antibodies »

Product Summary for RSK1 [p Thr359, p Ser363] Antibody (RM233)

Immunogen

A phospho-peptide corresponding to Human RSK1 [p Thr359, p Ser363]

Modification

p Thr359, p Ser363

Specificity

This antibody reacts to human RSK1 only when phosphorylated at Thr359/Ser363.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RSK1 [p Thr359, p Ser363] Antibody (RM233)

Western Blot: RSK1 [p Thr359, p Ser363] Antibody (RM233) [NBP2-61584] - Western Blot of A431 cells treated (+) or nontreated (-) with EGF, using NBP2-61584, showed a band of phosphorylated Rsk1 only in EGF treated A431 cells .
Immunohistochemistry-Paraffin: RSK1 [p Thr359, p Ser363] Antibody (RM233) [NBP2-61584] - Immunohistochemical staining of formalin fixed and paraffin embedded human cerebral cortex tissue sections using NBP2-61584.

Applications for RSK1 [p Thr359, p Ser363] Antibody (RM233)

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Western Blot

1:1000-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RSK1

Rsk-1 (p90-Rsk-1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes Rsk-1, Rsk-2 and Rsk-3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-Rsk-1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).

Long Name

Ribosomal Protein S6 Kinase I

Alternate Names

HU-1, MAPKAPL1A, RPS6KA1

Gene Symbol

RPS6KA1

Additional RSK1 Products

Product Documents for RSK1 [p Thr359, p Ser363] Antibody (RM233)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for RSK1 [p Thr359, p Ser363] Antibody (RM233)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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