Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark. Do not freeze.

Background: S1P1/EDG-1

EBP 50 [ERM (ezrin-radixin-moesin) binding phosphoprotein of 50 kDa] is a PDZ containing protein that is involved in the linkage of integral membrane proteins to the cytoskeleton. EBP50 contains two tandem PDZ domains followed by a carboxy-terminal sequence that binds to members of the ERM family of membrane-cytoskeleton adaptors. The PDZ domains within EBP50 bind to the carboxy termini of such target proteins as beta2 adrenergic receptor, platelet-derived growth factor receptor (PDGFR), and the cystic fibrosis conductance regulator (CFTR). The PDZ domains are also believed to be involved in the oligomerization of EBP 50 to form multiprotein complexes which helps to facilitate the formation of functional signalling complexes. EBP 50 has been shown to link integral membrane proteins to the cytoskeleton by binding to members of the ERM family of proteins, which bind to F-actin. Through these interactions, EBP 50 is implicated in the localization of interactive groups of proteins into subcellular domains and in the regulation of activity of those interacting proteins. Immunohistochemical studies have shown that EBP 50 is found exclusively at the apical membranes of epithelial cells.

Long Name

Endothelial Differentiation Gene 1

Alternate Names

CD363, EDG1, S1PR1

Gene Symbol

S1PR1

Additional S1P1/EDG-1 Products

Product Documents for S1P1/EDG-1 Antibody (MM0045-21L9) [PE/Cy7]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for S1P1/EDG-1 Antibody (MM0045-21L9) [PE/Cy7]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

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Flow Cytometry

S1P1/EDG-1 Antibody (MM0045-21L9) [PE/Cy7]

Novus Biologicals, part of Bio-Techne | Catalog # NB110-93513PECY7

Key Product Details

Species Reactivity

Validated:

Applications

Label

Antibody Source

Concentration

View all S1P1/EDG-1 Antibodies »

Product Summary for S1P1/EDG-1 Antibody (MM0045-21L9) [PE/Cy7]

Immunogen

Clonality

Host

Isotype

Applications for S1P1/EDG-1 Antibody (MM0045-21L9) [PE/Cy7]

Flow Cytometry

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: S1P1/EDG-1

Long Name

Alternate Names

Gene Symbol

Additional S1P1/EDG-1 Products

Product Documents for S1P1/EDG-1 Antibody (MM0045-21L9) [PE/Cy7]

Product Datasheets

COA

Certificate of Analysis

SDS

Product Specific Notices for S1P1/EDG-1 Antibody (MM0045-21L9) [PE/Cy7]

CONTACT INFORMATION

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