SDHB Antibody (SDHB/2126) [HRP]
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08809H
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Applications
Immunohistochemistry-Paraffin, Western Blot
Label
HRP
Antibody Source
Monoclonal Mouse IgG1 kappa Clone # SDHB/2126
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Summary for SDHB Antibody (SDHB/2126) [HRP]
Immunogen
Recombinant human SDHB fragment around aa 165-273 (Exact sequence is proprietary) (Uniprot: P21912 )
Reactivity Notes
Others not known.
Localization
Cytoplasmic (Mitochondria)
Specificity
Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation. Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.
Marker
Pheochromocytoma Marker
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1 kappa
Applications for SDHB Antibody (SDHB/2126) [HRP]
Application
Recommended Usage
Immunohistochemistry-Paraffin
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
PBS
Preservative
No Preservative
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: SDHB
Alternate Names
EC 1.3.5.1, FLJ92337, Ip, Iron-sulfur subunit of complex II, PGL4, SDH, SDH1, SDH2, SDHIP, succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Symbol
SDHB
Additional SDHB Products
Product Documents for SDHB Antibody (SDHB/2126) [HRP]
Product Specific Notices for SDHB Antibody (SDHB/2126) [HRP]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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