SEC61A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-768

Novus Biologicals, part of Bio-Techne
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NB100-768
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Porcine (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all SEC61A Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-KEQSEVGSMGALLF corresponding to C-Terminus according to NP_037468.1.

Epitope

C-KEQSEVGSMGALLF

Specificity

This antibody is designed to detect SEC61A1 and should not detect SEC61A2, but this has not been determined experimentally.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for SEC61A Antibody

Western Blot: SEC61A Antibody [NB100-768]

Western Blot: SEC61A Antibody [NB100-768]

Western Blot: SEC61A Antibody [NB100-768] - Analysis of SEC61A in Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer) using this antibody at 0.3 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for SEC61A Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:16000

Western Blot

0.3 - 1 ug/ml
Application Notes
WB: Approx. 48 kDa band observed in human brain (Cerebelum) lysates (calculated MW of 52.3 kDa band according to NP_037468.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SEC61A

SEC61A1 belongs to the SECY/SEC61 alpha family. It has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum.The SEC61 complex is responsible for translocation of proteins across the rough endoplasmic reticulum membrane. SEC61 is composed of three subunits: alpha, beta, and gamma; that associate to form a heterotrimer. Multiple heterotrimers associate forming the ER translocon. SEC61 alpha is a polytopic protein that has ten membrane-spanning loops. SEC61 has been found to be tightly associated with membrane bound ribosomes, either directly or through adaptor proteins, and is required for assembly of membrane and secretory proteins.

Alternate Names

HSEC61, protein transport protein SEC61 alpha subunit, protein transport protein Sec61 subunit alpha, protein transport protein Sec61 subunit alpha isoform 1, SEC61, Sec61 alpha 1 subunit (S. cerevisiae), Sec61 alpha-1, sec61 homolog, SEC61A

Entrez Gene IDs

29927 (Human)

Gene Symbol

SEC61A1

UniProt

NP_037468. (Human)

Additional SEC61A Products

Product Documents for SEC61A Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SEC61A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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