Senataxin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-13300

Novus Biologicals, part of Bio-Techne
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NBP2-13300
NBP2-13300-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Senataxin Antibodies »

Product Summary for Senataxin Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the amino acids: CCWCTPGGASTIDFLKRYASNTPSGEFQTADEDLCYCLECVAEYHKARDELPFLHEVLWELETLRLINHFEKSMKAEIGDDDELYIVDNNGEMPLFDITGQDFEN

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (85%), Rat (86%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Senataxin Antibody

Immunocytochemistry/ Immunofluorescence: Senataxin Antibody [NBP2-13300]

Immunocytochemistry/ Immunofluorescence: Senataxin Antibody [NBP2-13300]

Immunocytochemistry/Immunofluorescence: Senataxin Antibody [NBP2-13300] - Staining of human cell line RH-30 shows localization to nucleus & cytokinetic bridge. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Senataxin Antibody [NBP2-13300]

Immunohistochemistry-Paraffin: Senataxin Antibody [NBP2-13300]

Immunohistochemistry-Paraffin: Senataxin Antibody [NBP2-13300] - Staining of human pancreas shows no positivity in exocrine glanular cells as expected.
Immunohistochemistry-Paraffin: Senataxin Antibody [NBP2-13300]

Immunohistochemistry-Paraffin: Senataxin Antibody [NBP2-13300]

Immunohistochemistry-Paraffin: Senataxin Antibody [NBP2-13300] - Staining of human testis shows strong nuclear positivity in a subset of cells in seminiferous ducts.
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Applications for Senataxin Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Senataxin

Mutations in Senataxin result in the neurodegenerative disorders Ataxia-Oculomotor Apraxia 2 (AOA2) and amyotrophic lateral sclerosis (ALS4). Senataxin bears an RNA/DNA helicase domain suggesting a role in DNA and RNA processing and has recently been found to be involved in the DNA damage response. Alternate names for Senataxin include SEN1 homolog, SETX, ALS4, KIAA0625, SCAR1, and AOA2.

Alternate Names

ALS4recessive, non-Friedreich type 1, AOA2FLJ43459, DKFZp781B151, KIAA0625FLJ12840, senataxin, SETX

Gene Symbol

SETX

Additional Senataxin Products

Product Documents for Senataxin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Senataxin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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