Serpin F2/alpha 2-Antiplasmin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-96916

Novus Biologicals, part of Bio-Techne
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NB100-96916
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Serpin F2/alpha 2-Antiplasmin Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-KDFLQSLKGFPRGDK corresponding to internal region according to NP_000925.2, NP_001159393.1.

Specificity

This antibody is expected to recognize both reported isoforms (NP_000925.2; NP_001159393.1). Reported variants represent identical protein (NP_000925.2; NP_001159392.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Serpin F2/alpha 2-Antiplasmin Antibody

Western Blot: Serpin F2/alpha 2-Antiplasmin Antibody [NB100-96916]

Western Blot: Serpin F2/alpha 2-Antiplasmin Antibody [NB100-96916]

Western Blot: Serpin F2/alpha 2-Antiplasmin Antibody [NB100-96916] - Staining of HepG2 cell lysate (35 ug protein in RIPA buffer). Antibody at 0.1 ug/mL. Detected by chemiluminescence. Approx 70 kDa band observed in lysates of cell line HepG2 (calculated MW of 54.6 kDa according to NP_000925.2).
Immunocytochemistry/ Immunofluorescence: Serpin F2/alpha 2-Antiplasmin Antibody [NB100-96916]

Immunocytochemistry/ Immunofluorescence: Serpin F2/alpha 2-Antiplasmin Antibody [NB100-96916]

Immunocytochemistry/Immunofluorescence: Serpin F2/alpha 2-Antiplasmin Antibody [NB100-96916] - Immunofluorescence analysis of paraformaldehyde fixed A431 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).
Immunohistochemistry-Paraffin: Serpin F2/alpha 2-Antiplasmin Antibody [NB100-96916]

Immunohistochemistry-Paraffin: Serpin F2/alpha 2-Antiplasmin Antibody [NB100-96916]

Immunohistochemistry-Paraffin: Serpin F2/alpha 2-Antiplasmin Antibody [NB100-96916] - Staining of paraffin embedded Human Liver. Antibody at 3.8 ug/mL. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Applications for Serpin F2/alpha 2-Antiplasmin Antibody

Application
Recommended Usage

Flow Cytometry

10 ug/mL

Immunocytochemistry/ Immunofluorescence

10 ug/mL

Immunohistochemistry

3 - 5 ug/mL

Immunohistochemistry-Paraffin

3 - 5 ug/mL

Peptide ELISA

Detection limit 1:16000

Western Blot

0.3 - 1 ug/mL
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Serpin F2/alpha 2-Antiplasmin

Identification in human milk of complexes of matriptase with ATIII, A1AT, or A2AP, provides evidence that the proteolytic activity of matriptase, from cells that express no or low levels of HAI-1, may be controlled by secreted serpins. Sequencing analysis revealed the presence of two alpha2-PI gene variations, both in the second half of exon 10: a frameshift mutation and a G to A transition at nucleotide 11337 in codon 407. Observational study of gene-disease association. (HuGE Navigator). Thrombin activatable fibrinolysis inhibitor and alpha(2)-antiplasmin are not markers for recanalization in patients with ischemic stroke treated with recombinant tissue-type plasminogen activator. Fibrinolysis is amplified by converting alpha-antiplasmin from a plasmin inhibitor to a substrate. Hydroxyethyl starch (HES) dilution enhances fibrinolysis by diminishing alpha2-antiplasmin-plasmin interactions. the Arg6Trp polymorphism may play a significant role in governing the long-term deposition/removal of intravascular fibrin. TAFIa, PAI-1 and alpha-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots. Alpha2-antiplasmin has an important role in acute pulmonary embolism. Multiple Lys residues within alpha 2-antiplasmin contribute, perhaps in a zipper-like fashion, to its binding to the in-tandem, multikringle array that configures the plasmin heavy chain. alpha2-antiplasmin induction inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion

Alternate Names

alpha 2-Antiplasmin

Entrez Gene IDs

5345 (Human)

Gene Symbol

SERPINF2

UniProt

P08697

Additional Serpin F2/alpha 2-Antiplasmin Products

Product Documents for Serpin F2/alpha 2-Antiplasmin Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Serpin F2/alpha 2-Antiplasmin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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