SESN3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-31702

Novus Biologicals, part of Bio-Techne
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NBP1-31702
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Chimpanzee (100%), Rhesus Macaque (98%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all SESN3 Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human SESN3. The exact sequence is proprietary.

Reactivity Notes

Xenopus laevis (80%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SESN3 Antibody

Immunocytochemistry/ Immunofluorescence: SESN3 Antibody [NBP1-31702]

Immunocytochemistry/ Immunofluorescence: SESN3 Antibody [NBP1-31702]

Immunocytochemistry/Immunofluorescence: SESN3 Antibody [NBP1-31702] - Paraformaldehyde-fixed A549, using antibody at 1:200 dilution.
Western Blot: SESN3 Antibody [NBP1-31702]

Western Blot: SESN3 Antibody [NBP1-31702]

Western Blot: SESN3 Antibody [NBP1-31702] - A. 30 ug Rat 2 whole cell lysate/extract 7.5 % SDS-PAGESESN3 antibody dilution: 1:1000
Western Blot: SESN3 Antibody [NBP1-31702]

Western Blot: SESN3 Antibody [NBP1-31702]

Western Blot: SESN3 Antibody [NBP1-31702] - Various whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with SESN3 antibody diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
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Applications for SESN3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Immunohistochemistry-Paraffin

Reported in scientific literature (PMID: 29966750)

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: SESN3

Sestrin 3 (SESN3) is a member of the sestrin family of proteins, which modulate peroxide signaling and antioxident defense. p53, a tumor suppressor, regulates the expression of proteins in this family. SESN3 is a promising target for selectively killing cancer cells containing high levels of AKT, a protein kinase that is hyperactivated in cancer cells. AKT is involved in cell proliferation and protects cells from apoptosis.

Alternate Names

SEST3MGC29667, sestrin 3, sestrin-3

Gene Symbol

SESN3

Additional SESN3 Products

Product Documents for SESN3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for SESN3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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