SF20/MYDGF Antibody (S06-7B1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-20063

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-20063-100ul
NBP3-20063-50ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S06-7B1

Concentration

0.3 mg/ml

View all SF20/MYDGF Antibodies »

Product Summary for SF20/MYDGF Antibody (S06-7B1)

Immunogen

Recombinant protein of human SF20/MYDGF (Uniprot # Q969H8)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

19 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SF20/MYDGF Antibody (S06-7B1)

Western Blot: SF20/MYDGF Antibody (S06-7B1) [NBP3-20063]

Western Blot: SF20/MYDGF Antibody (S06-7B1) [NBP3-20063]

Western Blot: SF20/MYDGF Antibody (S06-7B1) [NBP3-20063] - Western blot detection of SF20/MYDGF in Hela, Jurkat cell lysates using NBP3-20063 (1:1000 diluted). Predicted band size: 19kDa. Observed band size: 19kDa.

Applications for SF20/MYDGF Antibody (S06-7B1)

Application
Recommended Usage

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SF20/MYDGF

Myeloid-Derived Growth Factor, or MYDGF, is a Bone marrow-derived monocyte protein, and it is correlated with enhanced metabolic activity, suppression of apoptosis, and stimulation of cell proliferation (1). MYDGF is expressed predominantly in inflammatory cells, such as monocytes and macrophages (1). Up-regulation of MYDGF expression was also found during adipocyte differentiation (2). Expression of MYDGF was induced in the circulation and heart tissue after myocardial infarction. It promotes cardiac myocyte survival by stimulating endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway, and inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (1). MYDGF was found over-expressed in approximately two-thirds of Hepatocellular Carcinoma (HCC) tissues, and its expression was significantly positively correlated with that of alpha-fetoprotein (AFP) (3). In HCC, MYDGF could regulate cell proliferation through activating Akt/mitogen-activated protein kinase pathways (3). Mouse MYDGF shares 92% amino acid sequence identity with both human and rat MYDGF. Intriguingly, virtually all homologs of MYDGF have a C-terminal putative ER retention sequence BXEL (B: Arg, His, or Lys; X: variable residue; E: Glu; L: Leu), which has the potential to retain human MYDGF and its homologs in the ER, whereas truncated MYDGF without BXEL is secreted from the cell (4). However, the functions of these different forms remain unclear.

Long Name

Stromal Cell-derived Growth Factor SF20

Alternate Names

C19orf10, Ly6elg, MYDGF

Gene Symbol

MYDGF

Additional SF20/MYDGF Products

Product Documents for SF20/MYDGF Antibody (S06-7B1)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SF20/MYDGF Antibody (S06-7B1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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