SHIP [p Tyr1020] Antibody (SR1167)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21565

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21565-100ul
NBP3-21565-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1167

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SHIP Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-SHIP [Tyr1020] (Uniprot #: Q92835)

Modification

p Tyr 1020

Specificity

Detects endogenous levels of phospho-SHIP [Tyr1020]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

145 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SHIP [p Tyr1020] Antibody (SR1167)

Western Blot: SHIP [p Tyr 1020] Antibody (SR1167) [NBP3-21565] -

Western Blot: SHIP [p Tyr 1020] Antibody (SR1167) [NBP3-21565] - Western blot analysis using NBP3-21565 in (1) Raji cell lysate; (2) Raji cell treated with pervanadate lysate.

Applications for SHIP [p Tyr1020] Antibody (SR1167)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunoprecipitation

1:20

Western Blot

1:1000-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SHIP

SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3, 4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2).

Long Name

SH2-containing Inositol Phosphatase

Alternate Names

INPP5D

Gene Symbol

INPP5D

Additional SHIP Products

Product Documents for SHIP [p Tyr1020] Antibody (SR1167)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SHIP [p Tyr1020] Antibody (SR1167)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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