Siglec-1/CD169 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-30903

Novus Biologicals, part of Bio-Techne
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NBP2-30903
NBP2-30903-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human, Mouse

Applications

Validated:

Dual RNAscope ISH-IHC, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Dual RNAscope ISH-IHC, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Siglec-1/CD169 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: CTAQNLLGSISTIGRLQVEGARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYH

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Siglec-1/CD169 Antibody

Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903]

Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903]

Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903] - Staining of human placenta shows strong membranous positivity in Hofbauer cells.
Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903]

Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903]

Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903] - Staining of human lung shows strong membranous positivity in macrophages.
Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903]

Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903]

Immunohistochemistry-Paraffin: Siglec-1/CD169 Antibody [NBP2-30903] - Staining of human liver shows strong membranous positivity in Kupffer cells.
View 1 more images

Applications for Siglec-1/CD169 Antibody

Application
Recommended Usage

Dual RNAscope ISH-IHC

Reported in (PMID: 30930117)

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Siglec-1/CD169

The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.

Long Name

Sialic Acid Binding Ig-like Lectin 1

Alternate Names

CD169, Siglec1

Gene Symbol

SIGLEC1

UniProt

Q9BZZ2 (Human)

Additional Siglec-1/CD169 Products

Product Documents for Siglec-1/CD169 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Siglec-1/CD169 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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