SIRP alpha/CD172a Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-03074

Novus Biologicals, part of Bio-Techne
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NBP1-03074
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all SIRP alpha/CD172a Antibodies »

Product Specifications

Immunogen

A peptide corresponding to 17 aa near the C-terminus of human SIRP alpha/CD172a. The immunogen is located within the last 50 aa of SIRP alpha/CD172a.

Specificity

Recognizes SIRP alpha 1, 2 and 3.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SIRP alpha/CD172a Antibody - BSA Free

Immunohistochemistry-Paraffin: SIRP alpha/CD172a Antibody - BSA Free [NBP1-03074]

Immunohistochemistry-Paraffin: SIRP alpha/CD172a Antibody - BSA Free [NBP1-03074]

Immunohistochemistry-Paraffin: SIRP alpha/CD172a Antibody - BSA Free [NBP1-03074] - Staining of human placenta. Tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunohistochemistry-Paraffin: SIRP alpha/CD172a Antibody - BSA Free [NBP1-03074]

Immunohistochemistry-Paraffin: SIRP alpha/CD172a Antibody - BSA Free [NBP1-03074]

Immunohistochemistry-Paraffin: SIRP alpha/CD172a Antibody - BSA Free [NBP1-03074] - Staining of human testis. Tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Applications for SIRP alpha/CD172a Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:1000 - 1:2000

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1:1000-1:2000
Application Notes
.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SIRP alpha/CD172a

Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1), SHPS-1 (2,3), MyD-1 (4), BIT (5,6) and p84 (7). SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2 (1,2,5,8). SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes (1,2,5,8).

Long Name

Signal-regulatory Protein alpha

Alternate Names

BIT, CD172a, MFR, MYD-1, SHPS1, SIRPA

Entrez Gene IDs

19261 (Mouse); 25528 (Rat)

Gene Symbol

SIRPA

UniProt

P78324

Additional SIRP alpha/CD172a Products

Product Documents for SIRP alpha/CD172a Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SIRP alpha/CD172a Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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