SIRP beta 1/gamma Antibody (OX117) - Chimeric - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81072

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Immunoprecipitation

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # OX117

Format

Azide and BSA Free

Concentration

1 mg/ml

View all SIRP beta 1/gamma Antibodies »

Product Specifications

Immunogen

Recombinant human SIRPgamma:CD4 fusion protein.

Specificity

This antibody binds to human SIRP beta 1/gamma.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Scientific Data Images for SIRP beta 1/gamma Antibody (OX117) - Chimeric - Azide and BSA Free

Flow Cytometry: SIRP beta 1/gamma Antibody (OX117) - Chimeric - Azide and BSA Free [NBP2-81072]

Flow Cytometry: SIRP beta 1/gamma Antibody (OX117) - Chimeric - Azide and BSA Free [NBP2-81072]

Flow Cytometry: SIRP beta 1/gamma Antibody (OX117) - Chimeric [NBP2-81072] - Flow-cytometry using [NBP2-81072]. Human lymphocytes were stained with an isotype control (NBP2-52638, panel A) or the rabbit-chimeric version of OX117 (NBP2-81072, panel B) at a concentration of 1 ug/ml for 30 mins at RT. After washing, bound antibody was detected using a AF488 conjugated donkey anti-rabbit antibody and cells analysed on a FACSCanto flow-cytometer.

Applications for SIRP beta 1/gamma Antibody (OX117) - Chimeric - Azide and BSA Free

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. This antibody binds to human Signal-regulatory protein gamma, an immunoglobulin-like cell surface receptor binding CD47. It mediates cell-cell adhesion and enhances T-cell activation.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

0.02% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

Background: SIRP beta 1/gamma

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Long Name

Signal-regulatory Protein beta 1/gamma

Alternate Names

CD172 antigen-like family member B, CD172b, signal-regulatory protein beta-1, SIRP-BETA-1

Gene Symbol

SIRPB1

Additional SIRP beta 1/gamma Products

Product Documents for SIRP beta 1/gamma Antibody (OX117) - Chimeric - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for SIRP beta 1/gamma Antibody (OX117) - Chimeric - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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