SIRT7 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56364

Novus Biologicals, part of Bio-Techne
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NB100-56364
NB100-56364SS
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all Sirtuin 7/SIRT7 Antibodies »

Product Specifications

Immunogen

A mixture of synthetic peptides corresponding to amino acids 35-51 and 361-377 of human SIRT7 was used as immunogen.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SIRT7 Antibody

Western Blot: SIRT7 Antibody [NB100-56364]

Western Blot: SIRT7 Antibody [NB100-56364]

Western Blot: SIRT7 Antibody [NB100-56364] - Immunoblots reveal the levels of sirtuins (SIRT4-7) in the OSCC cell lines HSC-3, UM-SCC-1, and UM-SCC-17B and in normal human oral keratinocytes (K). B-Actin served as loading control. Antibodies include SIRT4 (NB100-1406), SIRT5 (NB100-56372), and SIRT7 (NB100-56364). Image collected and cropped by CiteAb from the following publication (doi.org/10.1002/cncr.25676) licensed under a CC-BY license.
Western Blot: SIRT7 Antibody [NB100-56364]

Western Blot: SIRT7 Antibody [NB100-56364]

Western Blot: SIRT7 Antibody [NB100-56364] - Analysis of SIRT7 in A) human liver and B) PBMC lysate using this antibody at 1 ug/ml.

Applications for SIRT7 Antibody

Application
Recommended Usage

Western Blot

1-3 ug/ml
Application Notes
There is no corresponding 40 kD band seen in mouse or rat liver cell lysate.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Sirtuin 7/SIRT7

SIRT7 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.

Long Name

NAD-Dependent Protein Deacetylase Sirtuin-7

Alternate Names

SIR2L7

Gene Symbol

SIRT7

UniProt

Q9NRC8 (Human)

Additional Sirtuin 7/SIRT7 Products

Product Documents for SIRT7 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SIRT7 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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