Skp2 Antibody (S08-0A2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19917

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19917-100ul
NBP3-19917-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S08-0A2

Concentration

0.3 mg/ml

View all Skp2 Antibodies »

Product Summary for Skp2 Antibody (S08-0A2)

Immunogen

A synthetic peptide of human Skp2 (Uniprot # Q13309)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

48 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Skp2 Antibody (S08-0A2)

Immunocytochemistry/ Immunofluorescence: Skp2 Antibody (S08-0A2) [NBP3-19917]

Immunocytochemistry/ Immunofluorescence: Skp2 Antibody (S08-0A2) [NBP3-19917]

Immunocytochemistry/Immunofluorescence: Skp2 Antibody (S08-0A2) [NBP3-19917] - Immunocytochemistry of Skp2 (green) in hela using NBP3-19917 at dilution 1/50, and DAPI (blue)

Applications for Skp2 Antibody (S08-0A2)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1/20
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Skp2

The critical role that the family of regulatory proteins known as cyclins plays in eukaryotic cell cycle regulation is well established. The best characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of MPF (maturation promoting factor). Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin dependent kinase 2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DP-1 and E2F, and retinoblastoma protein p110. Two cyclin A-Cdk2 complex binding proteins, Skp1 p19 and Skp2 p45, have been described. Although the Skps (S phase kinase-associated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit any regulatory effects on the complex. Abolition of Skp2 p45 function by either microinjection of anti-p45 antibodies or addition of antisense oligonucleotides prevents entry into S phase of both normal and transformed cells.

Long Name

S Phase Kinase-associated Protein 2

Alternate Names

FBL1, FBXL1, p45skp2

Gene Symbol

SKP2

Additional Skp2 Products

Product Documents for Skp2 Antibody (S08-0A2)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Skp2 Antibody (S08-0A2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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