Slug Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27182

Novus Biologicals, part of Bio-Techne
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NBP2-27182
NBP2-27182SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Canine, Equine

Cited:

Human, Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all Slug Antibodies »

Product Specifications

Immunogen

Amino acids 82-110 of human SNAIL2 (SNAI2) were used as the immunogen.

Reactivity Notes

Rat SNAIL2 (SNAI2) (89%). Mouse reactivity reported in scientific literature (PMID: 26240017)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

30 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Slug Antibody

Western Blot: Slug Antibody [NBP2-27182]

Western Blot: Slug Antibody [NBP2-27182]

Western Blot: Slug Antibody [NBP2-27182] - Analysis of extracts from HepG2 cells using Slug antibody (NBP2-27182) at 1:1000.
Immunohistochemistry: Slug Antibody [NBP2-27182]

Immunohistochemistry: Slug Antibody [NBP2-27182]

Immunohistochemistry: Slug Antibody [NBP2-27182] - Analysis of liver cancer using Slug antibody (NBP2-27182) at 1:25. Image objective 400X.
Immunohistochemistry: Slug Antibody [NBP2-27182]

Immunohistochemistry: Slug Antibody [NBP2-27182]

Immunohistochemistry: Slug Antibody [NBP2-27182] - Analysis of gastric cancer using Slug antibody (NBP2-27182) at 1:25. Image objective 100X.
View 1 more images

Applications for Slug Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

1:2000
Application Notes
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Slug

Zinc finger transcription factor SNAIL2 (SNAI2, Slug) is found to have some functional significance in formation of axis and mesoderm in Drosophila. SNAIL2 and Twist act as negative regulators of level of Cerberus RNA, which encodes a Nodal, bone morphogenic protein (BMP) and WNT inhibitor. mRNA levels of SNAIL2 are regulated by NF-kappaB in early embryo. Partial functional redundancy between Twist, SNAIL2 and SNAIL1 may be developmentally and physiologically significant given their roles in the induction and progression of various forms of epithelial-mesenchymal transition and the metastasis of cancer cells, the regulation of apoptosis, and their ability to generate stem cell like behaviors in immortalized human epithelial cells.

Alternate Names

SLUGH1, SNAI2, SNAIL2, WS2D

Gene Symbol

SNAI2

Additional Slug Products

Product Documents for Slug Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Slug Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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