SMAC/Diablo Antibody (RM271)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61586

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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NBP2-61586
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM271

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SMAC/Diablo Antibodies »

Product Summary for SMAC/Diablo Antibody (RM271)

Immunogen

A peptide corresponding to the C-terminus of Human SMAC/Diablo

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SMAC/Diablo Antibody (RM271)

Western Blot: SMAC/Diablo Antibody (RM271) [NBP2-61586]

Western Blot: SMAC/Diablo Antibody (RM271) [NBP2-61586]

Western Blot: SMAC/Diablo Antibody (RM271) [NBP2-61586] - HeLa and MCF-7 cells lysates using Anti-Smac/Diablo Rabbit Monoclonal Antibody at a 1:1000 dilution.
Immunohistochemistry-Paraffin: SMAC/Diablo Antibody (RM271) [NBP2-61586]

Immunohistochemistry-Paraffin: SMAC/Diablo Antibody (RM271) [NBP2-61586]

Immunohistochemistry-Paraffin: SMAC/Diablo Antibody (RM271) [NBP2-61586] - Immunohistochemical staining of formalin fixed and paraffin embedded Human breast cancer tissue sections using NBP2-61586.

Applications for SMAC/Diablo Antibody (RM271)

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500-1:1000

Western Blot

1:1000-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SMAC/Diablo

Smac/DIABLO is a mitochondrial protein which activates various forms of apoptosis. Specifically, Smac exits the mitochondria and enters the cytosol where it initiates apoptosis by neutralizing members of the IAP family of apoptosis inhibitory proteins. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms.

Long Name

Second Mitochondria-derived Activator of Caspase

Alternate Names

Diablo

Gene Symbol

DIABLO

Additional SMAC/Diablo Products

Product Documents for SMAC/Diablo Antibody (RM271)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SMAC/Diablo Antibody (RM271)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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