SMC1 [p Ser957] Antibody (1F9)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26388

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 1F9

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SMC1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from Human SMC1 [p Ser957] [UniProt Q14683]

Modification

p Ser 957

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SMC1 [p Ser957] Antibody (1F9)

SMC1 [p Ser957] Antibody (1F9)

Western Blot: SMC1 [p Ser957] Antibody (1F9) [NBP3-26388] -

Western Blot: SMC1 [p Ser957] Antibody (1F9) [NBP3-26388] - Positive Western Blot detected in 293 whole cell lysate (treated with Calyculin A or not).
All lanes: SMC1 [p Ser957] Antibody at 1.11ug/ml.
Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution.
Predicted band size: 160 KDa
Observed band size: 160 KDa

Applications for SMC1 [p Ser957] Antibody (1F9)

Application
Recommended Usage

Western Blot

1:500-1:5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl and 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: SMC1

SMC1 is involved in chromosome cohesion during cell cycle and in DNA repair. It is a central component of the cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, SMC1 works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint.

Long Name

Structural Maintenance of Chromosomes 1

Alternate Names

SB1.8, SMC1A, SMC1L1

Gene Symbol

SMC1A

Additional SMC1 Products

Product Documents for SMC1 [p Ser957] Antibody (1F9)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SMC1 [p Ser957] Antibody (1F9)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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