SMC1 [p Ser957] Antibody (SR1229)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21544

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1229

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SMC1 Antibodies »

Product Summary for SMC1 [p Ser957] Antibody (SR1229)

Immunogen

A synthesized peptide derived from human phospho-SMC1 [Ser957] (Uniprot #: Q14683)

Modification

p Ser 957

Specificity

Detects endogenous levels of phospho-SMC1 [Ser957]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

160 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SMC1 [p Ser957] Antibody (SR1229)

Immunohistochemistry: SMC1 [p Ser 957] Antibody (SR1229) [NBP3-21544] -

Immunohistochemistry: SMC1 [p Ser 957] Antibody (SR1229) [NBP3-21544] - Immunohistochemical analysis of paraffin-embedded human bladder cancer, using NBP3-21544.

Western Blot: SMC1 [p Ser 957] Antibody (SR1229) [NBP3-21544] -

Western Blot: SMC1 [p Ser 957] Antibody (SR1229) [NBP3-21544] - Western blot analysis using NBP3-21544 in (1) HeLa cell lysate; (2) Hela cells lysate treated with AP.

Applications for SMC1 [p Ser957] Antibody (SR1229)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SMC1

SMC1 is involved in chromosome cohesion during cell cycle and in DNA repair. It is a central component of the cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, SMC1 works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint.

Long Name

Structural Maintenance of Chromosomes 1

Alternate Names

SB1.8, SMC1A, SMC1L1

Gene Symbol

SMC1A

Additional SMC1 Products

Product Documents for SMC1 [p Ser957] Antibody (SR1229)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SMC1 [p Ser957] Antibody (SR1229)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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