SOCS-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56637

Novus Biologicals, part of Bio-Techne
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NB100-56637
NB100-56637SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all SOCS-1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to amino acids 54-68 (HFRTFRSHADYRRIT) of human SOCS1 was used as immunogen (NP_003736.1)

Reactivity Notes

This should cross-react with rat SOCS1, based on amino acid sequence.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

23.55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SOCS-1 Antibody

Western Blot: SOCS-1 Antibody [NB100-56637]

Western Blot: SOCS-1 Antibody [NB100-56637]

Western Blot: SOCS-1 Antibody [NB100-56637] - Analysis of SOCS-1 using NB100-56637 at 1:1000 dilution against 15 ug/lane of Ramos (A) and Raw (B) cell lysate.

Applications for SOCS-1 Antibody

Application
Recommended Usage

Western Blot

1:500-1:1000
Application Notes
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 1 review rated 1 using NB100-56637 in the following applications:

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole antisera with PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SOCS-1

The suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS) inhibit cytokine production by a classical negative feedback mechanism. These proteins are upregulated in response to cytokine stimulation followed by inhibition of cytokine-inducing signal pathway. Role of each members of the family has been determined by gene knockout experiments (1). SOCS1 also known as JAB and (STAT)-induced STAT inhibitor 1 (SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signaling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin (1). SOCS1/JAB is rapidly induced by LPS and negatively regulates LPS signaling (2). SOCS1 (-/-) mice are very sensitive to LPS. These mice die prematurely, probably due to uncontrolled IFN-g signaling (3).

Long Name

Suppressor Of Cytokine Signaling 1

Alternate Names

CIS1, Cish1, JAB, SOCS1, SSI-1, TIP3

Entrez Gene IDs

8651 (Human); 12703 (Mouse)

Gene Symbol

SOCS1

UniProt

O15524 (Human)

Additional SOCS-1 Products

Product Documents for SOCS-1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SOCS-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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