SOCS-3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27210

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Feline, Primate

Predicted:

Chimpanzee (100%), Orangutan (100%), Porcine (94%), Rhesus Macaque (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

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Product Specifications

Immunogen

A portion of amino acids 110-160 from human SOCS3 was used as the immunogen for this antibody.

Reactivity Notes

The amino acid sequence used as immunogen for this antibody is 100% homologous in rhesus monkey, orangutan, european pole-cat, and chimpanzee; 94% in new world monkey and pig; 89% in panda, dog, chinese hamster, and horse; 83% in cow, african bush elephant, mouse, sheep, and rat; and 61% homologous in guinea pig.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SOCS-3 Antibody

Western Blot: SOCS-3 Antibody [NBP2-27210]

Western Blot: SOCS-3 Antibody [NBP2-27210]

Western Blot: SOCS-3 Antibody [NBP2-27210] - Analysis of SOCS3. Jurkat lysate in the 1) absence and 2) presence of immunizing peptide probed with 4 ug/ml of SOCS3 antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry-Paraffin: SOCS-3 Antibody [NBP2-27210]

Immunohistochemistry-Paraffin: SOCS-3 Antibody [NBP2-27210]

Immunohistochemistry-Paraffin: SOCS-3 Antibody [NBP2-27210] - Human kidney probed with SOCS3 antibody at 5 ug/ml.

Applications for SOCS-3 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5ug/ml~

Western Blot

1-5ug/ml

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SOCS-3

SOCS3 is a member of the suppressor of cytokine signaling family with a molecular weight of ~ 25 kDa. It is also an SSI or stat-induced stat inhibitor protein. IL-6, for example, induces SOCS3 expression and in turn SOCS3 negatively regulates IL-6 induced immune signaling and inflammatory pathways. SOCS3 is also induced by IL-10 and IFNgamma (1-3). SOCS3 plays an important role in the initial stages of B-cell development and differentiation (1). IL-6, IL-10, and IFNgamma feedback loops and likely involvement of SOCS3 may also be critical in controlling and fine-tuning the inflammatory responses of activated macrophages through TLR ligands, a direct involvement therefore of SOCS3 in innate immune signaling pathways (4, 5) . SOCS3 antibody provides an opportunity to identify and clarify the SOCS3 feedback control mechanism in host defense, innate immunity and autoimmune inflammatory cascades.

Long Name

Suppressor Of Cytokine Signaling 3

Alternate Names

ATOD4, CIS3, Cish3, SOCS3, SSI-3

Gene Symbol

SOCS3

Additional SOCS-3 Products

Product Documents for SOCS-3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for SOCS-3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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