Somatostatin R1/SSTR1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-120

Novus Biologicals, part of Bio-Techne
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NB300-120
NB300-120SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Somatostatin R1/SSTR1 Antibodies »

Product Summary for Somatostatin R1/SSTR1 Antibody

Immunogen

A synthetic peptide from the C-terminus of rat Somatostatin Receptor 1, conjugated to cysteine. [UniProt# P28646]

Specificity

Specific to Somatostatin Receptor I (SSR1) and does not react with Somatostatin Receptor II (SSR2).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

60 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Somatostatin R1/SSTR1 Antibody

Western Blot: Somatostatin R1/SSTR1 Antibody [NB300-120]

Western Blot: Somatostatin R1/SSTR1 Antibody [NB300-120]

Western Blot: Somatostatin Receptor 1 Antibody [NB300-120] - Detection of SSR1 from rat pancreas using NB300-120 (1:1000).

Applications for Somatostatin R1/SSTR1 Antibody

Application
Recommended Usage

Immunoprecipitation

1:10-1:500

Western Blot

1:1000-1:5000
Application Notes
This Somatostatin Receptor 1 antibody is useful for Immunoprecipitation and Western blot, where a band is seen at 60 kDa representing Somatostatin Receptor 1. This antibody is not suitable for use in Immunocytochemistry/Immunofluorescence.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole antisera

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Somatostatin R1/SSTR1

Somatostatin is a widely expressed circulating peptide hormone that has been involved in different biological processes including hormone secretion inhibition, neuronal transmission modulation, regulation of cell growth etc., and somatostatin's effects are mediated by a family of GPCRs "somatostatin Receptor-1 to -5" (SSTR1-5) that are differentially expressed in tumours and normal tissues including CNS/PNS, endocrine system and digestive canal. Once these receptors are activated, somatostatin exerts well-characterized direct/indirect antiproliferative effects in a variety of epithelial and endocrine cells. Somatostatin directly antagonizes the mitogenic action of EGF in pancreatic tumor cells and antagonizes additional tyrosine kinases in other cell types. SSTR1 belongs to GPCR1 family and it is a somatostatin receptor with higher affinity for somatostatin-14 than -28. SSTR1 is coupled to phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins, and is widely expressed in normal tissues as well as tumors.

Long Name

Somatostatin Receptor Type 1

Alternate Names

SomatostatinR1, SRIF-2, SS1R, SSTR1

Entrez Gene IDs

6751 (Human); 20605 (Mouse); 25033 (Rat)

Gene Symbol

SSTR1

UniProt

P28646 (Rat)

Additional Somatostatin R1/SSTR1 Products

Product Documents for Somatostatin R1/SSTR1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Somatostatin R1/SSTR1 Antibody

Licensed to Novus Biologicals LLC under U.S. Patent No 5,998,154.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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