Somatostatin R3/SSTR3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-74538

Novus Biologicals, part of Bio-Techne
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NB100-74538
NB100-74538-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Somatostatin R3/SSTR3 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues C Q(385) E R P P S R V A(393) of human SSTR3.

Specificity

Somatostatin Receptor 3

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Somatostatin R3/SSTR3 Antibody

Immunohistochemistry-Paraffin: Somatostatin R3/SSTR3 Antibody [NB100-74538]

Immunohistochemistry-Paraffin: Somatostatin R3/SSTR3 Antibody [NB100-74538]

Immunohistochemistry-Paraffin: Somatostatin R3/SSTR3 Antibody [NB100-74538] - Staining of SSTR3 in human pancreatic islands.

Applications for Somatostatin R3/SSTR3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:5000

Immunohistochemistry

1:2500

Immunohistochemistry-Paraffin

1:2500

Western Blot

1:5000

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole serum

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Somatostatin R3/SSTR3

Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Long Name

Somatostatin Receptor Type 3

Alternate Names

SomatostatinR3, SSR-28, SST3, SSTR3

Entrez Gene IDs

6753 (Human)

Gene Symbol

SSTR3

UniProt

P32745

Additional Somatostatin R3/SSTR3 Products

Product Documents for Somatostatin R3/SSTR3 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Somatostatin R3/SSTR3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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