SOX11 Antibody (SOX11/3235R) [Janelia Fluor® 635]
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08594JF635
Recombinant Monoclonal Antibody
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry-Paraffin
Label
Janelia Fluor 635
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # SOX11/3235R
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Recombinant fragment (around aa300-400) of human SOX11 protein (Uniprot: P35716 )
Localization
Nuclear (Cervix); Cytoplasmic (Melanoma)
Specificity
Recognizes a protein of ~47kDa, identified as SOX11. This monoclonal antibody is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5%-10% of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL.
Marker
Mantle Cell Lymphoma Marker
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Applications for SOX11 Antibody (SOX11/3235R) [Janelia Fluor® 635]
Application
Recommended Usage
Immunohistochemistry-Paraffin
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: SOX11
Long Name
Transcription Factor SRY (Sex Determining Region Y)-box 11
Alternate Names
SRY (sex determining region Y)-box 11, SRY (sex-determining region Y)-box 11, SRY-related HMG-box gene 11, transcription factor SOX-11
Gene Symbol
SOX11
Additional SOX11 Products
Product Documents for SOX11 Antibody (SOX11/3235R) [Janelia Fluor® 635]
Product Specific Notices for SOX11 Antibody (SOX11/3235R) [Janelia Fluor® 635]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Loading...
Loading...
Loading...
Loading...